Endocrine Abstracts

A 59 yr old man was admitted with sweating, tremors and generalized weakness. Blood tests showed FT4>100 pmol/l, FT3>50 pmol/l, TSH<0.01 mU/l, neutrophils 0.6×109 /l Past medical history included recurrent hyperthyroidism, type 2 diabetes mellitus, and neutropenia of ‘unknown’ origin(under investigation by haematology). Carbimazole 20 mg BD was started 2 days prior to admission by his general practitioner.The neutrop...

Introduction: In the UK, the North West of England is one of the worst affected regions by COVID 19, with over 275 cases/100,000. We retrospectively looked at the diabetes characteristics of consecutive patients at our trust admitted with COVID 19 and had known diabetes, and assessed whether there was a correlation with the outcome, Clinical Frailty Score (CFS) and age.Methods: 88 continuous patients with a prior diagnosis of diabetes and COVID 19 swab p...

Obesity is associated with a significantly increased risk of diabetes, cardiovascular disease and some cancers together with numerous other medical problems. During the last 10 years in particular, there has been a conceptual transformation of adipose tissue from an inert store of energy into an active endocrine organ that participates in the maintenance of normal energy homeostasis through its interactions with organs such as muscle, liver and the brain. In addition, it has b...

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A 56 year old lady was diagnosed with cancer of unknown primary after the discovery of liver metastases. Prior to the commencement of EOX chemotherapy (epirubicin, oxaliplatin and capecitabine) she was given a dose of 4 mg zolendronic acid for hypercalcaemia of malignancy. Three weeks later she presented to our hospital with a history of rapid decline and reduced oral intake, with associated diarrhoea. She had reduced GCS and hypotension. Initial investigations revealed an acu...

Case 1: A 32 year old fit and well female presented with symptoms of thyrotoxicosis and goitre. Her initial investigations revealed fT4 45 pmol/l (10–20) and fT3 26 pmol/l (3.5–6.5), with undetectable TSH. TSH receptor antibodies were positive. She was commenced on beta blockers and carbimazole and increased to 60 mg daily, with the fT4 improving only to 34.4 and fT3 to 13.8. Cholestyramine was commenced and titrated to a dose of 4 g twice daily, with resultant norma...

Background: In obese patients compared to non-obese subjects, serum immunoreactive parathyroid hormone (PTH) is higher and decreases with weight loss.Objectives: To find out if obesity affects the vitamin D endocrine system and if the resulting secondary hyperparathyroidism is linked to a decrease in urine calcium.Material and Methods: 25 healthy individuals were examined. Between the ages of 21-30 years, there were 13 obese people...

Introduction: Maternal thyroid function is put under stress during pregnancy. Thyroid disorder is very common among expectant mothers. 10% of pregnancies have subclinical hypothyroidism. Anemia, low birth weight, and neonatal mental retardation are among side effects of hypothyroidism during pregnancy.Objective: The primary and main objective is to evaluate the results for pregnant women with abnormal thyroid profiles, both for the mother and the fetus. ...

Objective: To investigate the effects of BPA on oxidative damage in terms of activity level of antioxidant enzymes in different regions of the rat brain.Background: The ever increasing uses of electronic gadgets are becoming a widespread source of Bisphenol-A accumulation. As studies have been reported that low level BPA accumulation may produce neurological effects but still limited studies have re-examined for its adverse effects in terms of acute expo...

We describe a 82 year old patient with background history of thyrotoxicosis (had total thyroidectomy), primary hyperparathyroidism (had parathyroidectomy 12 years back at another hospital – two glands removed). She was on L-thyroxine, alfacalcidiol 1 μg/day and CaCO3 500 mg BD. She remained stable for 7 years on this cocktail. In February 2017, she was admitted with acute confusion and was found to have adjusted ca level of 4.57 with AKI, no...